Indication
HIV/AIDS
HIV/AIDS - Entry inhibitor program
Entry inhibitors are a class of antiretroviral drugs which targets key proteins involved in the HIV entry process, interfering with the virus binding, fusion and entry to a host cell.
Peptide-based lead compounds identified by Ambrilia:
- Active on various HIV isolates
- Active on CXCR4 & CCR5 expressing cells
- Soluble and easy to synthesize
Small molecule lead compounds identified by Ambrilia:
- High potency and specificity against HIV entry
- Limited competition with significant limitations in terms of safety and efficacy